2025年科研成果（2024.11.1-至今）
项目
1. 国家科技重大专项项目课题：冠脉综合征高出血风险高危人群的中医药防治临床研究
2. 国家中医药管理局科技专项课题：黄精药效物质基础解析及大健康产品开发
3. 国家中医药管理局科技专项课题：仙甲汤治疗前列腺增生症的作用机制及临床研究
4. 湖北省中医药管理局省级重大项目：黄精药效物质基础解析及大健康产品开发
5. 湖北省中医药管理局省级重大项目：仙甲汤治疗前列腺增生症的作用机制及临床研究
6. 湖北省自然科学基金面上项目：基于 m6A 甲基化修饰探讨人参皂苷 Rb1 延缓卵巢早衰的 RNA 表观遗传机制
7. 湖北省自然科学基金联合项目：基于“络以通为用”探讨补脏通络方外泌体 miRNA 调控“肠-肾轴”治疗糖尿病肾病的机制
8. 湖北省自然科学基金联合项目：天麻钩藤饮联合左旋多巴对慢性锰中毒致帕金森样病变的干预作用与机制
9. 湖北省自然科学基金联合项目：心悸不寐的免疫炎症机制及心脑同治法的干预作用研究
10. 湖北省自然科学基金联合项目：活血安神益智方通过代谢调控改善老年失眠大鼠学习记忆的机制研究
11. 湖北省自然科学基金联合项目：醒脑安神法择时给药对衰老模型昼夜节律的影响及作用机制研究
12. 湖北省自然科学基金联合项目：基于 Reelin 蛋白研究父代肾虚影响仔鼠大脑皮层发育的机制
13. 湖北省自然科学基金联合项目：蕲艾中草甘膦残留量的高通量快检平台的建立
14. 湖北省自然科学基金联合项目：枳实薤白桂枝汤防治胸痹的物质基础与作用机制研究
15. 湖北省自然科学基金联合项目：基于人群队列的中医体质特征与非酒精性脂肪性肝炎的相关性及生物学机制研究
16. 湖北省自然科学基金联合项目：基于“肺与大肠相表里”探讨达原饮调节肠道微生态治疗痰湿瘀滞型肺结节的效应机制
17. 湖北省自然科学基金联合项目：基于“运转枢机”法探讨柴胡四物汤介导 FABP1/PPARs信号通路调控巨噬细胞极化改善绝经后女性脂代谢紊乱的作用机制
18. 湖北省中医药管理局重点项目：以少棘蜈蚣为例研究药用动物药效成分地理差异的调控机制
19. 湖北省中医药管理局面上项目：基于“脏虚络痹”探讨补脏通络方调节组蛋白乳酸化修饰调控 METTL3/m6A/KCNH6 表达改善肺纤维化机制研究
20. 湖北省中医药管理局青年项目：基于 Reelin -糖酵解信号研究“先天肾虚”与 ASD 神经元突触缺陷相关 性研究
21. 湖北省中医药管理局指导性项目：基于多重信号放大的 CRISPR 生物传感新技术用于中药材中典型痕量真菌毒素的现场准确超灵敏检测研究
论文 （#共同第一作者，*共同通讯作者）
一区
1. Zhang J#, Huang H#, Xiao M, Jiang X, Yang Y, Huang M, Wang S, Zhu B*, Zhao M*. 2025. Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway. Phytomedicine. 143:156852.
2. Liu Y#, Wang F#, Hu H, Zhang Z, Yang H, Yao X, Liu H*, Zheng J*. 2025. A paper-based label-free plasmonic nanosensor for portable pre-diagnosis of multiple metabolic diseases. Biosensors and Bioelectronics. 275:117231.
3. Wang Q#, Liu S#, Zhu T, Hu B, Huang Y, Gao Y, Xiong L, Cao L, Zhang Z*, Liu H*. 2025. Structure characteristics and fermentation properties of konjac oligosaccharides from konjac peel prepared by one-step fermentation with Bacillus Licheniformis BJ2022. Food Chemistry. 484:144332.
4. Zhu T, Liu S, Gao Y, Sun X, Hu H, Zhang Z, Zhang W, Xiong L*, Liu H*. 2025. Functional Characterization of a Highly Efficient Endoglucanase from Bacillus licheniformis BJ2022 and Its Application in the Preparation of Low-Molecular-Weight Konjac Glucomannan. Journal of Agricultural and Food Chemistry. 73:8367-8380.
二区
1. Dong J#, Fu Y-X#, Zheng B-F, Chen M-X, Chen Q, Wishwajith K, Dong J*, Lin H-Y*, Yang G-F*. 2025. Repurposing 4-Hydroxyphenylpyruvate dioxygenase inhibitors as novel agents for mosquito control: A structure-based design approach. International Journal of Biological Macromolecules. 315:144566.
2. Cao L, Chang MX*. 2025. Zebrafish CD44a variants suppress antiviral immunity through regulation of RIG-I ubiquitination and degradation. Fish & Shellfish Immuonology. 163:110442.
3. Shao Y#, Tao Q#, Shao L, Bi J, Wang Q, Wang Z, Sun X*. 2025. Defective UIO66 metal-organic framework nanoparticles assisted by cascade isothermal amplification technology for the detection of aflatoxin B1. Talanta. 285:127411.
4. He X#, Zhang Y#, Fang H, Ma N, Yan X, Yang H, Cao L, Xu L, Hu H*, Liu H*. 2025. Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology. Journal of Functional Foods. 128:106841.
5. Xiang X#, Liu Y#, Zeng Z, Zhao X, Shi Q, Huang X, Yang H, Song C, Xu S*, Jin S*. 2025. Exploration of the mechanism of fermented turmeric preventing glucolipid metabolic disorder: Insights into signaling of microbiota-SCFAs-brown adipose tissue axis in mice. Journal of Functional Foods. 125:106675.
6. Huang Y#, Jin S#, Huang R, Zeng , Zhan Z, Yuan H, Li D, Dai M*, Wang W*, Chen C*. 2025. Chemical profiles changes in Belamcanda chinensis: A metabolomic analysis of crude and processed samples. CHinese Journal of Analytical Chemistry. Doi:10.1016/j.cjac.2025.100559.
7. Lv J, Liu W, Wang F, Xiong L, Yang H, Yao X, Liu H*, Zheng J*. 2025. Multi-target microfluidic loop-mediated isothermal amplification technology for the detection of foodborne pathogens in various food matrices. Analytica Chimica Acta. 1346. 343751.
8. Li Y#, Zhang Z#, Xiong L, Zheng J, Zhu T, Li J, Lin A*, Liu H*. 2025. A novel salt-adapted bifunctional glucanase/mannanase from Klebsiella pneumoniae and its application in oligosaccharide production. International Journal of Biological Macromolecules. 296:139678.
9. Zhu B#, Zhang Z#, Xie Y, Huang M, Chen Y, Yang Y, Shi X, Han J, Yang L, Zhao M*. 2025. Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity. Ecotoxicology and Environmental Safety. 289:117646.
10. Ai Z#, Yuan D#, Dong R, Zhou S*, Cao J*. 2025. Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation. J Ethnopharmacol. Doi: 10.1016/j.jep.2024.119297
11. Zhang CY, Hu HL, Wang Y, Zhang L*, Ding GH*. 2024. Combined effects of thermal environment and gene regulation on metabolic enzyme activities of major metabolic tissues in a winter-breeding amphibian. Journal of Thermal Biology. 125:104000.
12. Zhang K, Dayananda B, Liu Y, Hu Z*, Zhang L*. 2024. Spatial and temporal variation of precipitation driven the genome size variation in Scolopendra in Chinese mainland. Ecology and Evolution. 14:e70580.
13. Zeng Z#, Hu X#, Zhao X, Xiang X, Zhang L, Cao S, Zhang Y, Chen C, Huang R*, Jin S*, Song C*. 2025.Integrating transcriptomics and metabolomics to uncover key metabolic mechanisms of mistletoe parasitism on diverse hosts. Environmental and Experimental Botany. 229:106077.
14. Zhang Y#, Liu S#, Cao D, Zhao M, Lu H*, Wang P*. 2024. Rg1 Improves Alzheimer's disease by Regulating Mitochondrial Dynamics Mediated by the AMPK/Drp1 Signaling Pathway. J Ethnopharmacol 27:119285.
15. Chen J, Huang B*, Liu Y, Sun X, Xiong L, Zhu T, Yao X, Hu H*, Liu H*. 2025. Characterization of a novel cold-active β-Xylosidase from Parabacteroides distasonis and its synergistic hydrolysis of beechwood xylan. Int J Biol Macromol. 284:137895.
16. Jiang X#, Yu X#, Zhu Z, Lyu Y, Jiang X, Liu Z, Cao J*, Xiao M*. 2025. Shenling Baizhu San improves spermatogenic dysfunction in hyperuricemia mice by regulating Sirt3/Nrf2 to inhibit testicular ferroptosis. Journal of Ethnopharmacology. 340:119310.
17. Xie Y#, Ouyang T#, Xu A, Bian Q, Zhu B*, Zhao M*. 2025. Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes. Drug Design Develoment and Therapy. 19: 2189-2203.
18. Lyu H, Fan N, Wen H, Zhang X, Mao H, Bian Q, Chen J*. 2025. Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis. Nutrition and Metabolism.22:7.
19. Zhang L*, Zhu W*, ur Rehman K*, Li H*. 2025. Gut microbiota's role in high-altitude animal adaptation. Frontiers in Microbiology. 16:1613028.
20. Yang Q, Sun J, Yang Z, Rastogi S, Liu YF*,
Zhao BB*. 2024. Evaluation of the efficacy of chlorhexidine-alcohol vs.
aqueous/alcoholic iodine solutions for the prevention of surgical site
infections: a systematic review and meta-analysis. Int J Surg. 110(11):7353-7366.
21. Chen H#, Zhang Z#, Song Y, Hu Q, Jin D, Liu S, Zu J, Zhang L, Ke M, Chen L*, Hu A*. 2025. Unraveling the therapeutic mechanisms of Bufei Yiqi decoction in pulmonary fibrosis: Modulation of autophagy and glycolysis pathways. International Immunopharmacology. 162:115030.
三区
1. Qu X#, You S#, Zeng Z, Zhao X, Zhang L, Li W, Huang R, Song C, He J, Li X*, Xiang X*, Jin S*. 2025. Component analysis of polyherbal repair recipe and its pharmacological mechanisms in burn wound healing. Burns. 51:107514.
2. Li J#, Gao Q#, Liu H, Liu S, Wang Y, Sun X, Zheng J, Yang H*, Hu B*. 2025. Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high-fat diet. Journal of Pharmaceutical and Biomedical Analysis. 259:116760.
3. Du L, *Zhu W, *Zhang L. 2025. Identification and characterization of the complete genome of the TGF-β gene family in Tupaia belangeri: Expression and function of adipose tissue under cold acclimation conditions. International Journal of Molecular Sciences. 26: 6681.
四区
1.Huang H, Duan B, Huang Z, Wang S, Wen Y, Jiang Q, Chen P, Huang P, Liu J, Zheng S, Ye Y, Zhang D, Wang Q, Huang F, Li J, Han L. 2025. Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules. Rapid Commun Mass Spectrom. 39(5):e9939.
